A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

Mike Casey; Claire M. Keaveney

doi:https://doi.org/10.1039/B312245J

A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

Mike Casey, Claire M. Keaveney

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A short stereoselective formal total synthesis of (±)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.

Original language	English
Pages (from-to)	184-185
Number of pages	2
Journal	Chemical Communications
Volume	4
Issue number	2
DOIs	https://doi.org/10.1039/B312245J https://doi.org/10.1039/b312245j
Publication status	Published - 2004
Externally published	Yes

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abstract = "A short stereoselective formal total synthesis of (±)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.",

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AB - A short stereoselective formal total synthesis of (±)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.

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A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

Abstract

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