A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

Mike Casey, Claire M. Keaveney

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A short stereoselective formal total synthesis of (±)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.

Original languageEnglish
Pages (from-to)184-185
Number of pages2
JournalChemical Communications
Volume4
Issue number2
DOIs
Publication statusPublished - 2004
Externally publishedYes

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