A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme: SS-24

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Tracey Coady (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor)

Research output: Patent

Abstract

The present invention relates to an isolated nitrile-metabolising Arthrobacter strain deposited under NCIMB 41855 and to amide or acid- producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrile­metabolising Arthrobacter strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is an isonitrile hydratase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing an amide or a carboxylic acid by metabolising nitrites such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxy-phenylpropionitrile to form corresponding amides and carboxylic acids.
Original languageEnglish (Ireland)
Patent number1111641.5
Filing date07/07/2011
Publication statusPublished - 07 Jul 2011

Keywords

  • Amides
  • Acids
  • Nitrile-Metabolising Enzyme

Fingerprint

Dive into the research topics of 'A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme: SS-24'. Together they form a unique fingerprint.

Cite this