A Process for Producing Amides and Acids using Nitrile-Metabolising Enzymes: SS-4

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor), Tracey Coady (Inventor)

Research output: Patent

Abstract

The present invention relates to an isolated nitrile-metabolising Pantoea strain deposited under NCIMB 41853 and to amide or acid-producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrile-metabolising Pantoea strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is a nitrilase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing a carboxylic acid by metabolising nitriles such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxy­phenylpropionitrile to form corresponding carboxylic acids.
Original languageEnglish (Ireland)
Patent number1111637.3
Filing date07/07/2011
Publication statusPublished - 07 Jul 2011

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