A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine

Emma Drinkall; Matthew J. Wass; Tracey J. Coffey; Robin J. Flynn

doi:10.1016/j.vetimm.2017.07.009

A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine

Emma Drinkall, Matthew J. Wass, Tracey J. Coffey, Robin J. Flynn

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Veterinary Immunology and Immunopathology
Volume	191
DOIs	https://doi.org/10.1016/j.vetimm.2017.07.009
Publication status	Published - Sep 2017
Externally published	Yes

Keywords

Biopsy
Bovine
Cryptosporidium parvum
IL-17A
Intestine
Villi

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vetimm.2017.07.009

Cite this

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title = "A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine",

abstract = "Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage.",

keywords = "Biopsy, Bovine, Cryptosporidium parvum, IL-17A, Intestine, Villi",

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doi = "10.1016/j.vetimm.2017.07.009",

language = "English",

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T1 - A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine

AU - Drinkall, Emma

AU - Wass, Matthew J.

AU - Coffey, Tracey J.

AU - Flynn, Robin J.

PY - 2017/9

Y1 - 2017/9

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AB - Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage.

KW - Biopsy

KW - Bovine

KW - Cryptosporidium parvum

KW - IL-17A

KW - Intestine

KW - Villi

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ER -

A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine

Abstract

Keywords

UN SDGs

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