An analysis of the immune compartment within bovine adipose tissue

Eleanor G. Bentley, Glesni Pugh, Laura R. Gledhill, Robin J. Flynn

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Adipose tissue (AT) has wide functions as an active endocrine organ acting as a site of nutrient storage and thermogenesis. Recently it has been identified as having a key role in murine and human immunity and inflammation. Type 1 or type 2 immune responses and their respective cytokines have been linked to white or brown AT, respectively. Most dramatic is the involvement of type-2 innate lymphoid cells (ILC2s) in stimulating eosinophil recruitment via interleukin (IL)-13 which in turn stimulates alternative macrophage activation via IL-4/IL-13. Recruited leukocytes are capable of influencing the cellular composition and function of adipose tissue and present a route to combat human obesity, however these processes are poorly understood in ruminants. Here we have characterised the resident leukocytes populations within bovine mesenteric AT (MAT) and subcutaneous AT (SAT), compared with the corresponding mesenteric lymph node (MLN). Concurring with related studies, we find bovine AT has its own resident leukocyte populations where eosinophils and neutrophils dominate. Importantly the proportion of eosinophils or neutrophils corresponded to the adipocyte size found in both depots. Further exploration of this area may have important implications on the food production industry or could be applied to improve the course of pathogenesis during disease.

Original languageEnglish
Article number103411
JournalDevelopmental and Comparative Immunology
Volume100
DOIs
Publication statusPublished - Nov 2019
Externally publishedYes

Keywords

  • Adipose
  • Bovine
  • Eosinophil
  • Leukocyte
  • Mesenteric

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