Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's Immune Modulation Therapy

Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Systemic injection of lipopolysaccharide (LPS) blocks the expression of long-term potentiation in the hippocampus of the rat. This is coupled with increased IL-1β concentration and c-Jun NH2-terminal kinase activity, as well as an increase in the number of cells displaying apoptotic characteristics in the hippocampus. Vasogen's Immune Modulation Therapy (IMT) is a procedure involving intramuscular administration of syngeneic blood which has been exposed ex vivo to elevated temperature, oxidation and ultraviolet light. We report that Vasogen's IMT significantly abrogates these LPS-induced effects with a concomitant increase in the concentration of the anti-inflammatory cytokine IL-10. These data suggest that Vasogen's IMT may play a protective role against the deleterious effects of immune insults in the brain.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalNeuroImmunoModulation
Volume10
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Hippocampus
  • IL-1β
  • IL-10
  • Lipopolysaccharide
  • Long-term potentiation
  • Vasogen's IMT

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