Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's Immune Modulation Therapy

Yvonne Nolan; Aedín Minogue; Emily Vereker; Anthony E. Bolton; Veronica A. Campbell; Marina A. Lynch

doi:10.1159/000064413

Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's Immune Modulation Therapy

Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Systemic injection of lipopolysaccharide (LPS) blocks the expression of long-term potentiation in the hippocampus of the rat. This is coupled with increased IL-1β concentration and c-Jun NH₂-terminal kinase activity, as well as an increase in the number of cells displaying apoptotic characteristics in the hippocampus. Vasogen's Immune Modulation Therapy (IMT) is a procedure involving intramuscular administration of syngeneic blood which has been exposed ex vivo to elevated temperature, oxidation and ultraviolet light. We report that Vasogen's IMT significantly abrogates these LPS-induced effects with a concomitant increase in the concentration of the anti-inflammatory cytokine IL-10. These data suggest that Vasogen's IMT may play a protective role against the deleterious effects of immune insults in the brain.

Original language	English
Pages (from-to)	40-46
Number of pages	7
Journal	NeuroImmunoModulation
Volume	10
Issue number	1
DOIs	https://doi.org/10.1159/000064413
Publication status	Published - 2002
Externally published	Yes

Keywords

Hippocampus
IL-1β
IL-10
Lipopolysaccharide
Long-term potentiation
Vasogen's IMT

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10.1159/000064413

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abstract = "Systemic injection of lipopolysaccharide (LPS) blocks the expression of long-term potentiation in the hippocampus of the rat. This is coupled with increased IL-1β concentration and c-Jun NH2-terminal kinase activity, as well as an increase in the number of cells displaying apoptotic characteristics in the hippocampus. Vasogen's Immune Modulation Therapy (IMT) is a procedure involving intramuscular administration of syngeneic blood which has been exposed ex vivo to elevated temperature, oxidation and ultraviolet light. We report that Vasogen's IMT significantly abrogates these LPS-induced effects with a concomitant increase in the concentration of the anti-inflammatory cytokine IL-10. These data suggest that Vasogen's IMT may play a protective role against the deleterious effects of immune insults in the brain.",

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AU - Nolan, Yvonne

AU - Minogue, Aedín

AU - Vereker, Emily

AU - Bolton, Anthony E.

AU - Campbell, Veronica A.

AU - Lynch, Marina A.

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Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's Immune Modulation Therapy

Abstract

Keywords

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