Baseline assessment of 25-hydroxyvitamin d reference material and proficiency testing/external quality assurance material commutability: A Vitamin D Standardization Program Study

Karen W. Phinney, Christopher T. Sempos, Susan S.C. Tai, Johanna E. Camara, Stephen A. Wise, John H. Eckfeldt, Andrew N. Hoofnagle, Graham D. Carter, Julia Jones, Gary L. Myers, Ramon Durazo-Arvizu, W. Greg Miller, Lorin M. Bachmann, Ian S. Young, Juanita Pettit, Grahame Caldwell, Andrew Liu, Stephen P.J. Brooks, Kurtis Sarafin, Michael ThammGert B.M. Mensink, Markus Busch, Martina Rabenberg, Kevin D. Cashman, Mairead Kiely, Karen Galvin, Joy Y. Zhang, Michael Kinsella, Kyungwon Oh, Sun Wha Lee, Chae L. Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Sarah Meadows, Ann Prentice, Lu Tian, Patsy M. Brannon, Robyn M. Lucas, Peter M. Crump, Etienne Cavalier, Joyce Merkel, Joseph M. Betz

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

The Vitamin D Standardization Program (VDSP) coordinated a study in 2012 to assess the commutability of reference materials and proficiency testing/external quality assurance materials for total 25-hydroxyVitamin D [25(OH)D] in human serum, the primary indicator of Vitamin D status. A set of 50 single-donor serum samples as well as 17 reference and proficiency testing/external quality assessment materials were analyzed by participating laboratories that used either immunoassay or LC-MS methods for total 25(OH)D. The commutability test materials included National Institute of Standards and Technology Standard Reference Material 972a Vitamin D Metabolites in Human Serum as well as materials from the College of American Pathologists and the Vitamin D External Quality Assessment Scheme. Study protocols and data analysis procedures were in accordance with Clinical and Laboratory Standards Institute guidelines. The majority of the test materials were found to be commutable with the methods used in this commutability study. These results provide guidance for laboratories needing to choose appropriate reference materials and select proficiency or external quality assessment programs and will serve as a foundation for additional VDSP studies.

Original languageEnglish
Pages (from-to)1288-1293
Number of pages6
JournalJournal of AOAC International
Volume100
Issue number5
DOIs
Publication statusPublished - 01 Sep 2017
Externally publishedYes

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