Calculation of nanoparticle capture efficiency in magnetic drug targeting

P. J. Cregg, Kieran Murphy, Adil Mardinoglu

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In this 2D model large ferromagnetic particles are implanted as seeds to aid collection of multiple domain nanoparticles (radius ≈ 200 nm). Here, in contrast, single domain magnetic nanoparticles (radius in 20-100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C ++ finite volume library OpenFOAM. The simulations indicate that use of the Langevin function predicts greater collection efficiency than might be otherwise expected.

Original languageEnglish
Pages (from-to)3272-3275
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume320
Issue number23
DOIs
Publication statusPublished - Dec 2008

Keywords

  • High gradient magnetic separation (HGMS)
  • Magnetic drug targeting
  • Magnetic nanoparticle
  • Magnetic seed
  • Simulation

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