@inbook{0a098f2537f04b2d97ede14b114de320,
title = "CD95 and the MRL-lpr mouse model",
abstract = "CD95 (Fas-ligand) is a key mediator of cell death in multiple setting, thus its loss within the MRL-lpr (Faslpr) homozygote mice results in spontaneous autoimmunity. This is characterized by the development of arthritis and immune complex glomerulonephrosis making this strain a useful model for studying systemic lupus erythematosus. Herein we describe a method to exploit the heterozygote offspring of this strain in a model to study the effects of a CD95L blocking peptide on lupus-like disease in vivo.",
keywords = "CD95L, Fas-L, Fas, Kidney damage, Lupus, Mouse model of autoimmunity, MRL-lpr, SLE, T-cell",
author = "Flynn, {Robin J.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media LLC 2017.",
year = "2017",
doi = "10.1007/978-1-4939-6780-3_21",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "219--228",
booktitle = "Methods in Molecular Biology",
address = "United States",
}