Cell interactions and cytotoxic studies of cellulose nanofibers from Curauá natural fibers

Sivoney Ferreira Souza, Marcos Mariano, Dennys Reis, Christiane Bertachini Lombello, Mariselma Ferreira, Mohini Sain

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Cellulose nanofibers (CNF) were isolated from Curauá fibers (Ananas erectifolius L. B. Smith) through a mechanical grinder preceded by mild chemical treatment. Morphology and surface characteristics of the fibers were followed until it reaches the nanoscale as long and flexible nanofibers. In aqueous suspensions, SAXS techniques revealed that such nanofibers present a twisted ribbon structure while rheological measurements demonstrate its high viscosity and a thixotropic behavior. These characteristics suggests the potential application of CNF in biomedical field, which, in turn, stimulates the toxicological studies of such materials. The obtained materials do not show any sign of cytotoxicity by direct or indirect assays for cell viability and cell morphology using Vero cells. Moreover, during the adhesion test, the cells demonstrated higher affinity to the CNF surface. It can be related to its surface properties and its obtaining conditions, which did not use any hazardous chemicals.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalCarbohydrate Polymers
Publication statusPublished - 01 Dec 2018
Externally publishedYes


  • Biocompatibility
  • Microfibrillated cellulose
  • Nanocellulose
  • Nanofibrillated cellulose
  • Rheology
  • Tensile strength


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