Incorporation of thermosensitive active pharmaceutical ingredients for manufacturing multifunctional polymeric medical device is still limited as they can be deteriorated in the hot-melt extrusion process. In this study, the potential of sub and near-critical carbon dioxide for use as a green plasticiser was investigated. Pellethane thermoplastic polyurethane was hot melt extruded and its thermal and rheological behaviour were evaluated. The resultant extrudates were characterised using parallel-plate rotational rheometry and differential scanning calorimetry. The process temperature decreased from 185 to 160 °C. The rheology indicated that the melt viscosity reduced to 36.36% and 40.04% at 600 and 1000 psi, respectively. The results indicate that the employment of scCO2 as a transient plasticiser is a viable aid to conventional hot-melt extrusion and offers more opportunities for thermosensitive drugs to be coextruded at lower processing temperatures.
|Published - 2021
|2021 SPE Annual Technical Conference, ANTEC 2021 - Virtual, Online
Duration: 10 May 2021 → 21 May 2021
|2021 SPE Annual Technical Conference, ANTEC 2021
|10/05/2021 → 21/05/2021