Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract

Gillian E. Gardiner, Mary C. Rea, Brid O'Riordan, Paula O'Connor, Sheila M. Morgan, Peadar G. Lawlor, P. Brendan Lynch, Michael Cronin, R. Paul Ross, Colin Hill

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The component peptides of lacticin 3147 were degraded by α-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.

Original languageEnglish
Pages (from-to)7103-7109
Number of pages7
JournalApplied and Environmental Microbiology
Volume73
Issue number21
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

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