Gallic acid loaded disulfide cross-linked biocompatible polymeric nanogels as controlled release system: Synthesis, characterization, and antioxidant activity

Gautam Behl, Monal Sharma, Manisha Sikka, Saurabh Dahiya, Aruna Chhikara, Madhu Chopra

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

In this article, a sustained release formulation of the antioxidant gallic acid (GA) is presented in the form of glutathione responsive disulfide cross-linked poly(ethylene glycol)-based nanogels synthesized via aqueous inverse miniemulsion using atom transfer radical polymerization. The particle size was found to be in the range from 227 ± 51.78 to 573.3 ± 207.2 nm at three drug loading levels achieved i.e. 6.6, 14.26, and 18.29 wt.% of the nanogels with loading efficiency in the range of 60-70%. The release profile of the GA studied at three drug loading levels suggested a controlled release and the nanogels were capable of scavenging radicals and retained the antioxidant activity. The GA-loaded nanogels were found to be biocompatible on human cervical cancer cell lines (HeLa). DCFH-DA (2,7-dichlorofluorescin diacetate) assay evidenced that the nanogels were capable of scavenging the reactive oxygen species in cellular environment.

Original languageEnglish
Pages (from-to)865-881
Number of pages17
JournalJournal of Biomaterials Science, Polymer Edition
Volume24
Issue number7
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • ATRP
  • biodegradable
  • gallic acid
  • inverse miniemulsion
  • nanogels
  • ROS

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