Hydrogel-based Bio-nanomachine Transmitters for Bacterial Molecular Communications

Daniel P. Martins, Huong Q. O'Reilly, Lee Coffey, Paul D. Cotter, Sasitharan Balasubramaniam

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Bacterial quorum sensing can be engineered with a view to the design of biotechnological applications based on their intrinsic role as a means of communication. We propose the creation of a positive feedback loop that will promote the emission of a superfolded green fluorescence protein from a bacterial population that will flow through hydrogel, which is used to encapsulate the cells. These engineered cells are heretofore referred to as bio-nanomachine transmitters and we show that for lower values of diffusion coefficient, a higher molecular output signal power can be produced, which supports the use of engineered bacteria contained within hydrogels for molecular communications systems. In addition, our wet lab results show the propagation of the molecular output signal, proving the feasibility of engineering a positive feedback loop to create a bio-nanomachine transmitter that can be used for biosensing applications.

Original languageEnglish
Title of host publicationNanoCoCoA 2020 - Proceedings of the 1st ACM International Workshop on Nanoscale Computing, Communication, and Applications, Part of the 18th ACM Conference on Embedded Networked Sensor Systems, SenSys 2020
PublisherAssociation for Computing Machinery (ACM)
Pages14-19
Number of pages6
ISBN (Electronic)9781450381161
DOIs
Publication statusPublished - 16 Nov 2020
Externally publishedYes
Event1st ACM International Workshop on Nanoscale Computing, Communication, and Applications, NanoCoCoA 2020, held in conjunction with the 18th ACM Conference on Embedded Networked Sensor Systems, SenSys 2020 - Virtual, Online, Japan
Duration: 16 Nov 2020 → …

Publication series

NameNanoCoCoA 2020 - Proceedings of the 1st ACM International Workshop on Nanoscale Computing, Communication, and Applications, Part of the 18th ACM Conference on Embedded Networked Sensor Systems, SenSys 2020

Conference

Conference1st ACM International Workshop on Nanoscale Computing, Communication, and Applications, NanoCoCoA 2020, held in conjunction with the 18th ACM Conference on Embedded Networked Sensor Systems, SenSys 2020
Country/TerritoryJapan
CityVirtual, Online
Period16/11/2020 → …

Keywords

  • bio-nanomachines
  • engineered bacteria
  • nanocommunications

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