TY - JOUR
T1 - Hydrogels based on chitosan-xanthan for controlled release of theophylline
AU - Popa, Niculina
AU - Novac, Ovidiu
AU - Profire, Lenuta
AU - Lupusoru, Catalina Elena
AU - Popa, Marcel Ionel
N1 - Funding Information:
Acknowledgements The work was financially supported by Ministry of Education and Science Romania, project PNCD II 41-017/ 2007.
PY - 2010/4
Y1 - 2010/4
N2 - The aim of this paper is theophylline (THP) inclusion into xanthan-chitosan polyionic complex (Xa-CS) and the study of its in vitro and in vivo kinetic release. Xa-CS hydrogel was obtained by ionic complexation between two oppositely charged polysaccharides. THP was loaded into the Xa-CS matrix by diffusion of the drug solution. The obtained samples were characterized by FTIR spectroscopy, SEM microscopy and study of the swelling behavior. THP in vitro release experiments were carried out in conditions mimicking the gastrointestinal environment. The chosen drug dose for in vivo study was 15 mg THP/Kg body weight of THP powder or an equivalent dose in complex form. THP serum concentrations were determined by an HPLC assay. The THP peak serum concentration (C max) was 7.18 μg/ml for free THP and AUC 0-48 was 25.76 μg h/ml, while in the case of Xa-CS-THP, C max was of 5.72 μg/ml and AUC0-48 = 45.72 μg h/ml. The in vivo study regarding the behaviour of the obtained formulation, showed an increase bioavailability of THP compared to the raw drug, suggesting the possible application of the complex Xa-CS as an oral controlled drug delivery system in the management of chronic pulmonary obstructive disease.
AB - The aim of this paper is theophylline (THP) inclusion into xanthan-chitosan polyionic complex (Xa-CS) and the study of its in vitro and in vivo kinetic release. Xa-CS hydrogel was obtained by ionic complexation between two oppositely charged polysaccharides. THP was loaded into the Xa-CS matrix by diffusion of the drug solution. The obtained samples were characterized by FTIR spectroscopy, SEM microscopy and study of the swelling behavior. THP in vitro release experiments were carried out in conditions mimicking the gastrointestinal environment. The chosen drug dose for in vivo study was 15 mg THP/Kg body weight of THP powder or an equivalent dose in complex form. THP serum concentrations were determined by an HPLC assay. The THP peak serum concentration (C max) was 7.18 μg/ml for free THP and AUC 0-48 was 25.76 μg h/ml, while in the case of Xa-CS-THP, C max was of 5.72 μg/ml and AUC0-48 = 45.72 μg h/ml. The in vivo study regarding the behaviour of the obtained formulation, showed an increase bioavailability of THP compared to the raw drug, suggesting the possible application of the complex Xa-CS as an oral controlled drug delivery system in the management of chronic pulmonary obstructive disease.
UR - http://www.scopus.com/inward/record.url?scp=77951227627&partnerID=8YFLogxK
U2 - 10.1007/s10856-009-3937-4
DO - 10.1007/s10856-009-3937-4
M3 - Article
C2 - 19924518
AN - SCOPUS:77951227627
VL - 21
SP - 1241
EP - 1248
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 4
ER -