Improving the Capacity of Molecular Communication Using Enzymatic Reaction Cycles

Hamdan Awan, Chun Tung Chou

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

This paper considers the capacity of a diffusion-based molecular communication link assuming the receiver uses chemical reactions. The key contribution is we show that enzymatic reaction cycles, which is a class of chemical reactions commonly found in cells consisting of a forward and a backward enzymatic reaction, can improve the capacity of the communication link. The technical difficulty in analyzing enzymatic reaction cycles is that their reaction rates are nonlinear. We deal with this by assuming that the amount of certain chemicals in the enzymatic reaction cycle is large. In order to simplify the problem further, we use singular perturbation to study a particular operating regime of the enzymatic reaction cycles. This allows us to derive a closed-form expression of the channel gain. This expression suggests that we can improve the channel gain by increasing the total amount of substrate in the enzymatic reaction cycle. By using numerical calculations, we show that the effect of the enzymatic reaction cycle is to increase the channel gain and to reduce the noise, which results in a better signal-to-noise ratio and in turn a higher communication capacity. Furthermore, we show that we can increase the capacity by increasing the total amount of substrate in the enzymatic reaction cycle.

Original languageEnglish
Article number8039237
Pages (from-to)744-754
Number of pages11
JournalIEEE Transactions on Nanobioscience
Volume16
Issue number8
DOIs
Publication statusPublished - Dec 2017
Externally publishedYes

Keywords

  • chemical reaction based receiver
  • communication capacity
  • enzymatic reaction cycles
  • Molecular communication
  • signal-to-noise ratio

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