Abstract
Rationale:
An important feature of allergic asthma is lung fibrosis, which occurs during the chronic phase of the disease, and causes tissue remodelling. TGF-β1 and IL-13 are key pro-fibrotic agents, important for the activation of fibroblasts and macrophages during lung fibrosis. However, it is still unclear how these cytokines are induced.
Method:
Interleukin (IL)-25 is of critical importance for the initiation of acute type-2 responses due to its ability to rapidly induce IL-4, IL-5, and IL-13 effector cytokines. Here we investigate the role of IL-25 in the development of chronic lung fibrosis. A neutralising anti-IL-25 antibody was administered during chronic aerosol treatment to assess the effect of blocking IL-25 on lung fibrosis in a mouse model.
Results:
Neutralisation of IL-25, after the establishment of lung allergy, was able to prevent induction of lung arginase-1 activity and blocked the deposition of collagen in the lung. This …
An important feature of allergic asthma is lung fibrosis, which occurs during the chronic phase of the disease, and causes tissue remodelling. TGF-β1 and IL-13 are key pro-fibrotic agents, important for the activation of fibroblasts and macrophages during lung fibrosis. However, it is still unclear how these cytokines are induced.
Method:
Interleukin (IL)-25 is of critical importance for the initiation of acute type-2 responses due to its ability to rapidly induce IL-4, IL-5, and IL-13 effector cytokines. Here we investigate the role of IL-25 in the development of chronic lung fibrosis. A neutralising anti-IL-25 antibody was administered during chronic aerosol treatment to assess the effect of blocking IL-25 on lung fibrosis in a mouse model.
Results:
Neutralisation of IL-25, after the establishment of lung allergy, was able to prevent induction of lung arginase-1 activity and blocked the deposition of collagen in the lung. This …
| Original language | English (Ireland) |
|---|---|
| Pages | A6822-A6822 |
| Publication status | Published - 2010 |
| Event | American Thoracic Society International Conference - Duration: 14 May 2010 → 19 May 2010 |
Conference
| Conference | American Thoracic Society International Conference |
|---|---|
| Period | 14/05/2010 → 19/05/2010 |