Interleukin (IL)-25 is critical for the development of chronic lung fibrosis in mice

Robin Flynn

Research output: Contribution to conferenceAbstractpeer-review


An important feature of allergic asthma is lung fibrosis, which occurs during the chronic phase of the disease, and causes tissue remodelling. TGF-β1 and IL-13 are key pro-fibrotic agents, important for the activation of fibroblasts and macrophages during lung fibrosis. However, it is still unclear how these cytokines are induced.
Interleukin (IL)-25 is of critical importance for the initiation of acute type-2 responses due to its ability to rapidly induce IL-4, IL-5, and IL-13 effector cytokines. Here we investigate the role of IL-25 in the development of chronic lung fibrosis. A neutralising anti-IL-25 antibody was administered during chronic aerosol treatment to assess the effect of blocking IL-25 on lung fibrosis in a mouse model.
Neutralisation of IL-25, after the establishment of lung allergy, was able to prevent induction of lung arginase-1 activity and blocked the deposition of collagen in the lung. This …
Original languageEnglish (Ireland)
Publication statusPublished - 2010
EventAmerican Thoracic Society International Conference -
Duration: 14 May 201019 May 2010


ConferenceAmerican Thoracic Society International Conference


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