Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Tracey Coady (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor)

Research output: Patent

Abstract

The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.
Original languageEnglish (Ireland)
Patent numberPCT/EP2012/063323
IPCC12N 9/78 (2006.0 1),C12P 13/00 (2006.0 1),CUP 13/02 (2006.01)
Priority date07/07/2011
Filing date06/07/2012
Publication statusPublished - 10 Jan 2013

Keywords

  • Isolated nucleotide sequence
  • Polypeptide
  • Arthrobacter
  • NCIMB 41855

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