Leucine as an excipient in spray dried powder for inhalation

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9 Citations (Scopus)

Abstract

Leucine is a promising excipient with several applications in the development of inhalable spray-dried powder of high- and low-dose drugs. The addition of leucine has exhibited significant enhancing effects on the aerosolization and physical stability of the produced particles. Here, we focus not only on the applications of leucine in inhalable spray-drying powders, but also on the underlying mechanisms by which the formulation and processing parameters dictate the behavior of leucine during the drying process and, therefore, its functionalities within the dried powder. Additionally, we highlight the current regulatory status of leucine. Such insights are important for more efficient utilization of leucine in the future, both for dry powder inhaler formulations and other pharmaceutical applications.

Original languageEnglish
Pages (from-to)2384-2396
Number of pages13
JournalDrug Discovery Today
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Dry powder inhalers
  • Leucine
  • Particle engineering
  • Regulatory considerations
  • Spray drying

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