TY - JOUR
T1 - Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus
T2 - Evidence for a role for brain-derived neurotrophic factor
AU - Gooney, M.
AU - Shaw, K.
AU - Kelly, Á
AU - O'Mara, S. M.
AU - Lynch, M. A.
PY - 2002
Y1 - 2002
N2 - In this study, the authors investigate changes in the presynaptic terminal of the dentate gyrus that accompany 2 types of hippocampal-dependent plasticity: spatial learning and long-term potentiation (LTP). Parallel changes occurred in the dentate gyrus of rats that had undergone training in the Morris water maze and had sustained LTP. In both cases, KCI-induced brain-derived neurotrophic factor release was increased, and this was accompanied by increased phosphorylation of TrkB and the mitogen-activated protein kinase, ERK. Glutamate release was also enhanced, and the data suggest that this may be a consequence of increased activation of TrkB and ERK. Because the data indicate that similar cellular modifications are shared by these 2 forms of plasticity, they provide circumstantial evidence that LTP satisfies some of the requirements of a memory-inducing cellular substrate.
AB - In this study, the authors investigate changes in the presynaptic terminal of the dentate gyrus that accompany 2 types of hippocampal-dependent plasticity: spatial learning and long-term potentiation (LTP). Parallel changes occurred in the dentate gyrus of rats that had undergone training in the Morris water maze and had sustained LTP. In both cases, KCI-induced brain-derived neurotrophic factor release was increased, and this was accompanied by increased phosphorylation of TrkB and the mitogen-activated protein kinase, ERK. Glutamate release was also enhanced, and the data suggest that this may be a consequence of increased activation of TrkB and ERK. Because the data indicate that similar cellular modifications are shared by these 2 forms of plasticity, they provide circumstantial evidence that LTP satisfies some of the requirements of a memory-inducing cellular substrate.
UR - http://www.scopus.com/inward/record.url?scp=0035999634&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.116.3.455
DO - 10.1037/0735-7044.116.3.455
M3 - Article
C2 - 12049326
AN - SCOPUS:0035999634
VL - 116
SP - 455
EP - 463
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 3
ER -