Macular Carotenoids and Age-Related Maculopathy

Eamonn O'Connell, Kumari Neelam, John Nolan, Kah Guan Au Eong, Stephan Beatty

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Lutein (L) and zeaxanthin (Z) are concentrated at the macula, where they are collectively known as macular pigment (MP), and where they are believed to play a major role in protecting retinal tissues against oxidative stress. Whilst the exact pathogenesis of age-related maculopathy (ARM) remains unknown, the disruption of cellular processes by oxidative stress may play an important role. Manipulation of dietary intake of L and Z has been shown to augment MP, thereby raising hopes that dietary supplementation with these carotenoids might prevent, delay, or modify the course of ARM. This article discusses the scientific rationale supporting the hypothesis that L and Z are protective against ARM, and presents the recent evidence germane to this theory.

Original languageEnglish
Pages (from-to)821-830
Number of pages10
JournalAnnals of the Academy of Medicine Singapore
Issue number11
Publication statusPublished - Nov 2006


  • Lutein
  • Macular degeneration
  • Oxidative stress
  • Zeaxanthin


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