TY - JOUR
T1 - Magnetically tunable iron oxide nanotubes for multifunctional biomedical applications
AU - Das, Raja
AU - Cardarelli, Jason A.
AU - Phan, Manh Huong
AU - Srikanth, Hariharan
N1 - Funding Information:
Research at the University of South Florida was supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award No. DE-FG02-07ER46438.
Funding Information:
Research at the University of South Florida was supported by the U.S. Department of Energy, Office of Basic Energy Sciences , Division of Materials Sciences and Engineering under Award No. DE-FG02-07ER46438 .
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Design of a multifunctional magnetic bionanosystem has become increasingly important towards advancing the future of clinical medicine. While hollow iron oxide nanoparticles with enhanced surface areas allow for more drug molecules to be attached to the particles, their relatively low saturation magnetization (MS) hinders their practicality in medicinal applications such as drug delivery and hyperthermia therapy. We demonstrate that this limitation can be overcome by utilizing 1D magnetic nanotubes that possess both enhanced surface areas and high MS. In this study, highly crystalline, tunable aspect ratio Fe3O4 nanotubes have been successfully synthesized using a hydrothermal method. Magnetic measurements showed a clear Verwey transition (∼120 K) and high MS (∼75 emu/g) at 300 K, confirming the high quality of the synthesized Fe3O4 nanotubes. Calorimetric experiments on randomly dispersed Fe3O4 nanotubes in water with concentration of 1 mg/mL showed a large Specific Absorption Rate (SAR) value of 400 W/g for an AC magnetic field of 800 Oe, which increased to 500 W/g when the nanotubes were aligned parallel to the DC magnetic field and suspended in a 2% agar solution. Our study shows the possibility of using the Fe3O4 nanotubes as a highly effective multifunctional nanoscale tool for targeted hyperthermia and on-demand drug delivery.
AB - Design of a multifunctional magnetic bionanosystem has become increasingly important towards advancing the future of clinical medicine. While hollow iron oxide nanoparticles with enhanced surface areas allow for more drug molecules to be attached to the particles, their relatively low saturation magnetization (MS) hinders their practicality in medicinal applications such as drug delivery and hyperthermia therapy. We demonstrate that this limitation can be overcome by utilizing 1D magnetic nanotubes that possess both enhanced surface areas and high MS. In this study, highly crystalline, tunable aspect ratio Fe3O4 nanotubes have been successfully synthesized using a hydrothermal method. Magnetic measurements showed a clear Verwey transition (∼120 K) and high MS (∼75 emu/g) at 300 K, confirming the high quality of the synthesized Fe3O4 nanotubes. Calorimetric experiments on randomly dispersed Fe3O4 nanotubes in water with concentration of 1 mg/mL showed a large Specific Absorption Rate (SAR) value of 400 W/g for an AC magnetic field of 800 Oe, which increased to 500 W/g when the nanotubes were aligned parallel to the DC magnetic field and suspended in a 2% agar solution. Our study shows the possibility of using the Fe3O4 nanotubes as a highly effective multifunctional nanoscale tool for targeted hyperthermia and on-demand drug delivery.
KW - Biomagnetism
KW - Iron oxide
KW - Magnetic hyperthermia
KW - Nanotubes
UR - http://www.scopus.com/inward/record.url?scp=85062721392&partnerID=8YFLogxK
U2 - 10.1016/j.jallcom.2019.03.024
DO - 10.1016/j.jallcom.2019.03.024
M3 - Article
AN - SCOPUS:85062721392
VL - 789
SP - 323
EP - 329
JO - Journal of Alloys and Compounds
JF - Journal of Alloys and Compounds
SN - 0925-8388
ER -