Magnetically tunable iron oxide nanotubes for multifunctional biomedical applications

Raja Das, Jason A. Cardarelli, Manh Huong Phan, Hariharan Srikanth

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Design of a multifunctional magnetic bionanosystem has become increasingly important towards advancing the future of clinical medicine. While hollow iron oxide nanoparticles with enhanced surface areas allow for more drug molecules to be attached to the particles, their relatively low saturation magnetization (MS) hinders their practicality in medicinal applications such as drug delivery and hyperthermia therapy. We demonstrate that this limitation can be overcome by utilizing 1D magnetic nanotubes that possess both enhanced surface areas and high MS. In this study, highly crystalline, tunable aspect ratio Fe3O4 nanotubes have been successfully synthesized using a hydrothermal method. Magnetic measurements showed a clear Verwey transition (∼120 K) and high MS (∼75 emu/g) at 300 K, confirming the high quality of the synthesized Fe3O4 nanotubes. Calorimetric experiments on randomly dispersed Fe3O4 nanotubes in water with concentration of 1 mg/mL showed a large Specific Absorption Rate (SAR) value of 400 W/g for an AC magnetic field of 800 Oe, which increased to 500 W/g when the nanotubes were aligned parallel to the DC magnetic field and suspended in a 2% agar solution. Our study shows the possibility of using the Fe3O4 nanotubes as a highly effective multifunctional nanoscale tool for targeted hyperthermia and on-demand drug delivery.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalJournal of Alloys and Compounds
Publication statusPublished - 15 Jun 2019
Externally publishedYes


  • Biomagnetism
  • Iron oxide
  • Magnetic hyperthermia
  • Nanotubes


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