Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

P. J. Cregg, Kieran Murphy, Adil Mardinoglu, Adriele Prina-Mello

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter is considered both experimentally (in vitro) and theoretically. The results of a 2D mathematical model are compared with 3D experimental results for a magnetizable wire stent. In this experiment a ferromagnetic, coiled wire stent is implanted to aid collection of particles which consist of single domain magnetic nanoparticles (radius ≈ 10 nm). In order to model the agglomeration of particles known to occur in this system, the magnetic dipole-dipole and hydrodynamic interactions for multiple particles are included. Simulations based on this mathematical model were performed using open source C++ code. Different initial positions are considered and the system performance is assessed in terms of collection efficiency. The results of this model show closer agreement with the measured in vitro experimental results and with the literature. The implications in nanotechnology and nanomedicine are based on the prediction of the particle efficiency, in conjunction with the magnetizable stent, for targeted drug delivery.

Original languageEnglish
Pages (from-to)2087-2094
Number of pages8
JournalJournal of Magnetism and Magnetic Materials
Volume322
Issue number15
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Dipole-dipole interaction
  • High gradient magnetic separation (HGMS)
  • Hydrodynamic interaction
  • Magnetic drug targeting
  • Magnetic nanoparticle
  • Magnetizable stent
  • Simulation

Fingerprint

Dive into the research topics of 'Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting'. Together they form a unique fingerprint.

Cite this