MiRNA biogenesis and regulation of diseases: An overview

Anchal Vishnoi, Sweta Rani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

347 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied for their role in biological processes as well as in development and progression of various human diseases including retinal disorder, neurodegenerative diseases, cardiovascular disease and cancer. This chapter summarises miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs holds huge potential for diagnostic and prognostic biomarkers, and as predictors of drug response.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-10
Number of pages10
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1509
ISSN (Print)1064-3745

Keywords

  • Cancer
  • Cardiovascular disease
  • miRNA
  • Neurodegenerative diseases
  • Retinal disorder

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