Molecularly imprinted polymers for corticosteroids: Impact of polymer format on recognition behaviour

Laurence Fitzhenry, Panagiotis Manesiotis, Patrick Duggan, Peter McLoughlin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A comparative study was performed on different polymeric formats for targeting corticosteroids, focusing on the use of bulk monolith and precipitation polymerisation strategies. Hydrocortisone-17-butyrate was selected as the template and methacrylic acid as the functional monomer, following 1H NMR investigation of the pre-polymerisation mixture. Three different cross-linkers were tested, ranging from moderate to highly hydrophobic. The synthesised bulk and precipitated imprinted polymers were physically characterised by nitrogen sorption and evaluated by means of HPLC and frontal chromatography against a range of template analogues. While some degree of selectivity for the template was achieved for all tested polymers, the ones based on the tri-functional cross-linking monomer trimethylolpropane trimethacrylate exhibited the longest retention for all corticosteroids, especially in the precipitated format, which suggested broader group selectivity. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1421-1431
Number of pages11
JournalMicrochimica Acta
Issue number15-16
Publication statusPublished - Nov 2013


  • Budesonide
  • Corticosteroids
  • Hydrocortisone
  • Molecularly Imprinted Polymers (MIPs)
  • Precipitation polymerisation


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