Nanosensitive optical coherence tomography to assess wound healing within the cornea

CERINE LAL, SERGEY ALEXANDROV, SWETA RANI, YI ZHOU, THOMAS RITTER, MARTIN LEAHY

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though OCT offers high resolution imaging, the best ultra-high-resolution OCT systems are limited to imaging structural changes with a resolution of one micron on a single B-scan within very limited depth. Nanosensitive OCT (nsOCT) is a recently developed technique that is capable of providing enhanced sensitivity of OCT to structural changes. Improving the sensitivity of OCT to detect structural changes at the nanoscale level, to a depth typical for conventional OCT, could potentially improve the diagnostic capability of OCT in medical applications. In this paper, we demonstrate the capability of nsOCT to detect structural changes deep in the rat cornea following superficial corneal injury.

Original languageEnglish
Pages (from-to)3407-3422
Number of pages16
JournalBiomedical Optics Express
Volume11
Issue number7
DOIs
Publication statusPublished - 01 Jul 2020
Externally publishedYes

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