Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system

Ruqaiyyah Siddiqui, James Edwards-Smallbone, Robin Flynn, Naveed Ahmed Khan

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Transmigration of neuropathogens across the bloodbrain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented opportunities for the development of novel therapeutics.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalVirulence
Volume3
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Central nervous system
  • Human brain microvascular endothelial cells
  • Parasite
  • Traversal

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