Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

Daniel R. Neill, See Heng Wong, Agustin Bellosi, Robin J. Flynn, Maria Daly, Theresa K.A. Langford, Christine Bucks, Colleen M. Kane, Padraic G. Fallon, Richard Pannell, Helen E. Jolin, Andrew N.J. McKenzie

Research output: Contribution to journalArticlepeer-review

1527 Citations (Scopus)

Abstract

Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2 immunityresponsible for protective immune responses to helminth parasites1,2 and the underlying cause of the pathogenesis of allergic asthma3,4 consists of responses dominated by the cardinal type-2 cytokines interleukin (IL)4, IL5 and IL13 (ref. 5). T cells are an important source of these cytokines in adaptive immune responses, but the innate cell sources remain to be comprehensively determined. Here, through the use of novel Il13-eGFP reporter mice, we present the identification and functional characterization of a new innate type-2 immune effector leukocyte that we have named the nuocyte. Nuocytes expand in vivo in response to the type-2-inducing cytokines IL25 and IL33, and represent the predominant early source of IL13 during helminth infection with Nippostrongylus brasiliensis. In the combined absence of IL25 and IL33 signalling, nuocytes fail to expand, resulting in a severe defect in worm expulsion that is rescued by the adoptive transfer of in vitro cultured wild-type, but not IL13-deficient, nuocytes. Thus, nuocytes represent a critically important innate effector cell in type-2 immunity.

Original languageEnglish
Pages (from-to)1367-1370
Number of pages4
JournalNature
Volume464
Issue number7293
DOIs
Publication statusPublished - 29 Apr 2010
Externally publishedYes

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