Optimisation and use of water-in-oil MEEKC in pharmaceutical analysis

Margo Broderick; Sheila Donegan; Joe Power; Kevin Altria

doi:10.1016/j.jpba.2004.07.047

Optimisation and use of water-in-oil MEEKC in pharmaceutical analysis

Margo Broderick, Sheila Donegan, Joe Power, Kevin Altria

Department of Science

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Water-in-oil microemulsion electrokinetic chromatography has been applied to the separation of a range of acids, bases and neutrals and is especially suitable for very water-insoluble drug compounds. A number of operating parameters were evaluated. An optimised set of operating conditions allowed separation of a range of pharmaceutical formulations containing water-insoluble compounds. A number of novel applications for W/O microemulsions were developed and ability to quantify drug contents in tablets and a cream was shown with good precision, detector linearity and accuracy. Comparison of obtained data with those determined from a HPLC method showed acceptable agreement.

Original language	English
Pages (from-to)	877-884
Number of pages	8
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.jpba.2004.07.047
Publication status	Published - 29 Apr 2005

Keywords

W/O MEEKC

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10.1016/j.jpba.2004.07.047

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AU - Power, Joe

AU - Altria, Kevin

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Optimisation and use of water-in-oil MEEKC in pharmaceutical analysis

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Keywords

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