Parasite limiting macrophages promote IL-17 secretion in naive bovine CD4 + T-cells during Neospora caninum infection

Robin J. Flynn, Edward S. Marshall

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Neospora caninum infects bovine hosts giving rise to pro-inflammatory immune responses that can result in foetal death or spontaneous abortion, this appears to be mediated by the actions of IFN-γ on cell activation and migration/trafficking. Yet successful vaccination or natural immunity is also strongly correlated with IFN-γ production. We utilised in vitro infection of bovine macrophages to prime naive T-cell responses. Naive T-cells in contact with infected macrophages produce both IFN-γ and IL-17 in a pattern that is dependent on whether the priming macrophage was protected or non-protected. Our results may explain the apparent dual role of IFN-γ during infection if a second major pro-inflammatory cytokine, IL-17, is produced simultaneously.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalVeterinary Immunology and Immunopathology
Volume144
Issue number3-4
DOIs
Publication statusPublished - 15 Dec 2011
Externally publishedYes

Keywords

  • Bovine
  • IFN-γ
  • IL-17
  • Macrophage
  • Neospora caninum
  • T-cell

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