Probing critical physical properties of lactose-polyethylene glycol microparticles in pulmonary delivery of chitosan nanoparticles

Nasser Alhajj, Idanawati Naharudin, Paolo Colombo, Eride Quarta, Tin Wui Wong

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 µm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morphologies and crystallini-ties were prepared by a spray drying method using varying PEG molecular weights and ethanol contents. The chitosan nanoparticles were similarly prepared. In vitro inhalation performance and peripheral lung deposition of chitosan nanoparticles were enhanced through co-blending with larger lactose-PEG microparticles with reduced specific surface area. These microparticles had reduced inter-microparticle interaction, thereby promoting microparticle–nanoparticle interaction and facilitating nanoparticles flow into peripheral lung.

Original languageEnglish
Article number1581
JournalPharmaceutics
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2021
Externally publishedYes

Keywords

  • Chitosan
  • Lactose
  • Microparticle
  • Nanoparticle
  • Pulmonary delivery

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