TY - JOUR
T1 - Pulmonary hypertension and home-based (PHAHB) exercise intervention
T2 - Protocol for a feasibility study
AU - McCormack, Ciara
AU - Kehoe, Brona
AU - Hardcastle, Sarah J.
AU - McCaffrey, Noel
AU - McCarren, Andrew
AU - Gaine, Sean
AU - McCullagh, Brian
AU - Moyna, Niall
N1 - Funding Information:
Funding This work was supported by Janssen Sciences Ireland UC.
Publisher Copyright:
©
PY - 2021/5/10
Y1 - 2021/5/10
N2 - Introduction Novel therapies for pulmonary hypertension (PH) have improved survival and slowed disease progression. However, patients still present with symptoms of exertional dyspnoea and fatigue, which impacts their ability to perform activities of daily living, reduces exercise tolerance and impairs their quality of life (QoL). Exercise training has shown to be safe and effective at enhancing QoL and physical function in PH patients, yet it remains an underused adjunct therapy. Most exercise training for PH patients has been offered through hospital-based programmes. Home-based exercise programmes provide an alternative model that has the potential to increase the availability and accessibility of exercise training as an adjunct therapy in PH. The purpose of this study is to investigate the feasibility, acceptability, utility and safety of a novel remotely supervised home-based PH exercise programme. Methods Single arm intervention with a pre/post comparisons design and a follow-up maintenance phase will be employed. Eligible participants (n=25) will be recruited from the Mater Misericordiae University Hospital PH Unit. Participants will undergo a 10-week home-based exercise programme, with induction training, support materials, telecommunication support and health coaching sessions followed by a 10-week maintenance phase. The primary outcomes are feasibility, acceptability, utility and safety of the intervention. Secondary outcomes will include the impact of the intervention on exercise capacity, physical activity, strength, health-related QoL and exercise self-efficacy. Ethics and dissemination Ethics approval has been obtained from the Mater Misericordiae Institutional Review Board REF:1/378/2032 and Dublin City University Research Ethics DCUREC/2018/246. A manuscript of the results will be submitted to a peer-reviewed journal and results will be presented at conferences, community and consumer forums and hospital research conferences. Trial registration number ISRCTN83783446; Pre-results.
AB - Introduction Novel therapies for pulmonary hypertension (PH) have improved survival and slowed disease progression. However, patients still present with symptoms of exertional dyspnoea and fatigue, which impacts their ability to perform activities of daily living, reduces exercise tolerance and impairs their quality of life (QoL). Exercise training has shown to be safe and effective at enhancing QoL and physical function in PH patients, yet it remains an underused adjunct therapy. Most exercise training for PH patients has been offered through hospital-based programmes. Home-based exercise programmes provide an alternative model that has the potential to increase the availability and accessibility of exercise training as an adjunct therapy in PH. The purpose of this study is to investigate the feasibility, acceptability, utility and safety of a novel remotely supervised home-based PH exercise programme. Methods Single arm intervention with a pre/post comparisons design and a follow-up maintenance phase will be employed. Eligible participants (n=25) will be recruited from the Mater Misericordiae University Hospital PH Unit. Participants will undergo a 10-week home-based exercise programme, with induction training, support materials, telecommunication support and health coaching sessions followed by a 10-week maintenance phase. The primary outcomes are feasibility, acceptability, utility and safety of the intervention. Secondary outcomes will include the impact of the intervention on exercise capacity, physical activity, strength, health-related QoL and exercise self-efficacy. Ethics and dissemination Ethics approval has been obtained from the Mater Misericordiae Institutional Review Board REF:1/378/2032 and Dublin City University Research Ethics DCUREC/2018/246. A manuscript of the results will be submitted to a peer-reviewed journal and results will be presented at conferences, community and consumer forums and hospital research conferences. Trial registration number ISRCTN83783446; Pre-results.
KW - rehabilitation medicine
KW - respiratory physiology
KW - sports medicine
UR - http://www.scopus.com/inward/record.url?scp=85105723843&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2020-045460
DO - 10.1136/bmjopen-2020-045460
M3 - Article
C2 - 33972341
AN - SCOPUS:85105723843
SN - 2044-6055
VL - 11
JO - BMJ open
JF - BMJ open
IS - 5
M1 - e045460
ER -