Quality and Capacity Analysis of Molecular Communications in Bacterial Synthetic Logic Circuits

Daniel P. Martins, Michael Taynnan Barros, Sasitharan Balasubramaniam

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Synthetic logic circuits have been proposed as potential solutions for theranostics of biotechnological problems. One proposed model is the engineering of bacteria cells to create logic gates, and the communication between the bacteria populations will enable the circuit operation. In this paper, we analyze the quality of bacteria-based synthetic logic circuit through molecular communications that represent communication along a bus between three gates. In the bacteria-based synthetic logic circuit, the system receives environmental signals as molecular inputs and will process this information through a cascade of synthetic logic gates and free diffusion channels. We analyze the performance of this circuit by evaluating its quality and its relationship to the channel capacity of the molecular communications links that interconnect the bacteria populations. Our results show the effect of the molecular environmental delay and molecular amplitude differences over both the channel capacity and circuit quality. Furthermore, based on these metrics, we also obtain an optimum region for the circuit operation resulting in an accuracy of 80% for specific conditions. These results show that the performance of synthetic biology circuits can be evaluated through molecular communications, and lays the groundwork for combined systems that can contribute to future biomedical and biotechnology applications.

Original languageEnglish
Article number8772080
Pages (from-to)628-639
Number of pages12
JournalIEEE Transactions on Nanobioscience
Issue number4
Publication statusPublished - Oct 2019


  • Synthetic logic circuits
  • engineered bacteria
  • molecular communications


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