Real-time monitoring and control for high-efficiency autonomous laser fabrication of silicon nanoparticle colloids

Brian Freeland, Ronan McCann, Paul O’Neill, Sithara Sreenilayam, Manuel Tiefenthaler, Michal Dabros, Mandy Juillerat, Greg Foley, Dermot Brabazon

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Nanotechnology is a significant research tool for biological and medical research with major advancements achieved from nanoparticle (Np) applications in biosensing and biotherapeutics. For laser ablation synthesis in solution (LASiS) to be chosen by researchers for Np colloid production, the process must effectively compete with chemical synthesis in terms of produced colloid quality and productivity while taking advantage of LASiS benefits in terms of its ‘green-synthesis’ and single-step functionalisation abilities. In this work, a newly developed integrated LASiS Np manufacturing system is presented including a Np flow reactor design, an at-line Np size monitoring via 180° dynamic light scattering, and a UV-Vis spectroscopy system used to estimate colloid concentration and stability. The experimental outcomes are discussed in terms of Np productivity and quality via these at-line measurements from the UV-Vis and DLS systems. The developed instrument was validated via off-line SiNps DLS, UV-Vis and morphology tests via TEM. Ultra-high quality and nanoparticle fabrication rate efficiency was achieved and is reported here.

Original languageEnglish
Pages (from-to)291-304
Number of pages14
JournalInternational Journal of Advanced Manufacturing Technology
Issue number1-2
Publication statusPublished - May 2021
Externally publishedYes


  • Additive manufacturing
  • Dynamic light scattering
  • Laser ablation synthesis in solution
  • Nanoparticles
  • Real-line monitoring
  • Silicon nanoparticles
  • UV-Vis spectroscopy


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