Role of magnetic anisotropy on the hyperthermia efficiency in spherical Fe3−xCoxO4 (X = 0–1) nanoparticles

Raja Das, Ngoc Pham Kim, Supun B. Attanayake, Manh Huong Phan, Hariharan Srikanth

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The use of magnetic nanoparticles in the treatment of cancer using alternating current hyperthermia therapy has shown the potential to replace or supplement conventional cancer treat-ments, radiotherapy and chemotherapy, which have severe side effects. Though the nearly spherical sub-10 nm iron oxide nanoparticles have their approval from the US Food and Drug Administra-tion, their low heating efficiency and removal from the body after hyperthermia treatment raises serious concerns. The majority of magnetic hyperthermia research is working to create nanomaterials with improved heating efficiency and long blood circulation time. Here, we have demonstrated a simple strategy to enhance the heating efficiency of sub-10 nm Fe3O4 nanoparticles through the replacement of Fe+2 ions with Co+2 ions. Magnetic and hyperthermia experiments on the 7 nm Fe3−xCoxO4 (x = 0–1) nanoparticles showed that the blocking temperature, the coercivity at 10 K, and the specific absorption rate followed a similar trend with a maximum at x = 0.75, which is in corroboration with the theoretical prediction. Our study revealed that the heating efficiency of the Fe3−xCoxO4 (x = 0–1) nanoparticles varies not just with the size and saturation magnetization but also with the magnetocrystalline anisotropy of the particles.

Original languageEnglish
Article number930
Pages (from-to)1-10
Number of pages10
JournalApplied Sciences (Switzerland)
Issue number3
Publication statusPublished - 01 Feb 2021
Externally publishedYes


  • Heating efficiency
  • Hyperthermia
  • Iron oxide
  • Magneocrystalline
  • Magnetic anisotropy
  • Nanoparticles


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