SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue

S. Kennedy, M. Clynes, P. Doolan, J. P. Mehta, S. Rani, J. Crown, L. O'Driscoll

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The prevalence and clinical relevance of SNIP/p140Cap has not been extensively investigated. Here SNIP/p140Cap mRNA expression was studied in 103 breast tumour biopsies, where it was detected in ∼37% of tumour specimens, but not in any normal breast specimens. Expression correlated significantly with unfavourable overall survival. This suggests that SNIP/p140Cap may be a useful diagnostic and prognostic marker for breast cancer and its expression in breast cancer, but not in normal breast tissue, suggests that it may have potential as a therapeutic target.

Original languageEnglish
Pages (from-to)1641-1645
Number of pages5
JournalBritish Journal of Cancer
Volume98
Issue number10
DOIs
Publication statusPublished - 20 May 2008
Externally publishedYes

Keywords

  • Breast cancer
  • Disease/relapse-free survival
  • Overall survival
  • Quantitative reverse-transcriptase polymerase chain reaction (qPCR)
  • SNIP

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