Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration

Sarah Sabour-Pickett, Stephen Beatty, Eithne Connolly, James Loughman, Jim Stack, Alan Howard, Ronald Klein, Barbara E. Klein, Stacy M. Meuer, Chelsea E. Myers, Kwadwo O. Akuffo, John M. Nolan

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

PURPOSE:: To investigate the impact of three different macular carotenoid formulations on macular pigment optical density and visual performance in subjects with early age-related macular degeneration. METHODS:: Fifty-two subjects were supplemented and followed for 12 months, 17 of them were in intervention Group 1 (20 mg/day lutein and 2 mg/day zeaxanthin); 21 in Group 2 (10 mg/day meso-zeaxanthin, 10 mg/day lutein, and 2 mg/day zeaxanthin); and 14 in Group 3 (17 mg/day meso-zeaxanthin, 3 mg/day lutein, and 2 mg/day zeaxanthin). The macular pigment optical density was measured using customized heterochromatic flicker photometry, and visual function was assessed using corrected distance visual acuity and by letter contrast sensitivity. RESULTS:: A statistically significant increase in the macular pigment optical density was observed at all measured eccentricities in Group 2 (P ≤ 0.005) and in Group 3 (P < 0.05, for all), but only at 1.75° in Group 1 (P = 0.018). Statistically significant (P < 0.05) improvements in letter contrast sensitivity were seen at all spatial frequencies (except 1.2 cycles per degree) in Group 3, and at low spatial frequencies in Groups 1 and 2. CONCLUSION:: Augmentation of the macular pigment optical density across its spatial profile and enhancements in contrast sensitivity were best achieved after supplementation with a formulation containing high doses of meso-zeaxanthin in combination with lutein and zeaxanthin.

Original languageEnglish
Pages (from-to)1757-1766
Number of pages10
JournalRetina
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2014

Keywords

  • Age-related macular degeneration
  • Lutein
  • Meso-zeaxanthin
  • Visual performance
  • Zeaxanthin

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