Synthesis and characterization of N-(2-aminoethyl)-2-acetamidyl gellan gum with potential biomedical applications

O. Novac, G. Lisa, E. Barbu, F. Alhaique, M. I. Popa

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8 Citations (Scopus)

Abstract

N-(2-aminoethyl)-2-acetamidyl gellan gum (GCM-EDA) was prepared by carboxymethylation (via nucleophilic substitution of primary hydroxyl groups of the β-d-glucose unit of gellan gum, in the presence of alkali and chloroacetic acid) and reaction with tert-butyl N-(2-aminoethyl) carbamate (N-Boc-EDA) using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as an activator, followed by deprotection with trifluoroacetic acid. The structural confirmation and characterization of N-(2-aminoethyl)-2-acetamidyl gellan gum was performed by spectroscopic, rheological and thermogravimetric analysis, and in vitro tests showed a lack of cytotoxicity which is indicative of the potential of this material to be used in biomedical applications.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalCarbohydrate Polymers
Volume98
Issue number1
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Aminated derivative
  • Carboxymethylation
  • Cytotoxicity
  • Gellan gum
  • N-Boc deprotection
  • Rheology

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