The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing

Sweta Rani, Thomas Ritter

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)

Abstract

Wound healing is a complex process and often delayed in patients with underlying chronic conditions. The cost of wound care is a significant burden to the society, warranting new techniques to prompt wound healing. Several studies have reported on the beneficial effects of mesenchymal stem cells (MSCs) function in recruiting host cells, releasing secretory factors and matrix proteins thereby increasing wound heal. These secrete bioactive trophic factors from MSCs also includes extracellular vesicles (EVs) or exosomes. Recent studies have shown that EVs are one of the key secretory products of MSCs mediating cell-to-cell communication to enhance wound healing. Current knowledge related to the potential use of EVs in wound healing is reviewed and the promising future for EVs - a naturally secreted nanoparticle - as an alternative to cell-based therapy is discussed.

Original languageEnglish
Pages (from-to)5542-5552
Number of pages11
JournalAdvanced Materials
Volume28
Issue number27
DOIs
Publication statusPublished - 20 Jul 2016
Externally publishedYes

Keywords

  • cell-free
  • extracellular vesicles
  • mesenchymal stem cells
  • nanoparticles
  • wound healing

Fingerprint

Dive into the research topics of 'The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing'. Together they form a unique fingerprint.

Cite this