The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study: A randomised double-blind placebo-controlled study

Marina Green-Gomez, Alfonso Prado-Cabrero, Rachel Moran, Tommy Power, Laura G. Gómez-Mascaraque, Jim Stack, John M. Nolan

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561).

Original languageEnglish
Article number767
Pages (from-to)1-15
Number of pages15
JournalAntioxidants
Volume9
Issue number8
DOIs
Publication statusPublished - 18 Aug 2020

Keywords

  • Bioavailability
  • Carotenoid diacetates
  • Lutein
  • Meso-zeaxanthin
  • Micromicelles
  • Zeaxanthin

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