The role of female hormonal factors in the development of rheumatoid arthritis

Deshiré Alpízar-Rodríguez, Nicola Pluchino, Geraldine Canny, Cem Gabay, Axel Finckh

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)

Abstract

RA is the most common chronic systemic autoimmune disease, with a higher prevalence in women, suggesting female hormonal factors play a role in the development of the disease. However, many controversies still exist. The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime and interact with various environmental, immunological, genetic and endocrine factors influencing the development of autoimmunity. As some female hormonal factors may be potentially modifiable, understanding their impact on RA development is clinically relevant and may result in specific preventive interventions in high-risk populations.

Original languageEnglish
Pages (from-to)1254-1263
Number of pages10
JournalRheumatology (United Kingdom)
Volume56
Issue number8
DOIs
Publication statusPublished - 01 Aug 2017
Externally publishedYes

Keywords

  • Female hormonal factors
  • Reproductive factors
  • Rheumatoid arthritis
  • Risk factors
  • Women's health

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