Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication

Adil Mardinoglu, P. J. Cregg, Kieran Murphy, Maurice Curtin, Adriele Prina-Mello

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The magnetisable stent assisted magnetic targeted drug delivery system in a physiologically stretched vessel is considered theoretically. The changes in the mechanical behaviour of the vessel are analysed under the influence of mechanical forces generated by blood pressure. In this 2D mathematical model a ferromagnetic, coiled wire stent is implanted to aid collection of magnetic drug carrier particles in an elastic tube, which has similar mechanical properties to the blood vessel. A cyclic mechanical force is applied to the elastic tube to mimic the mechanical stress and strain of both the stent and vessel while in the body due to pulsatile blood circulation. The magnetic dipoledipole and hydrodynamic interactions for multiple particles are included and agglomeration of particles is also modelled. The resulting collection efficiency of the mathematical model shows that the system performance can decrease by as much as 10% due to the effects of the pulsatile blood circulation.

Original languageEnglish
Pages (from-to)324-329
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume323
Issue number3-4
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Dipoledipole interaction
  • Hydrodynamic interaction
  • Magnetic drug targeting
  • Magnetic nanoparticle
  • Magnetizable stent
  • Simulation
  • Stretch vessel

Fingerprint

Dive into the research topics of 'Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication'. Together they form a unique fingerprint.

Cite this