Ultrasound-based Control of Micro-Bubbles for Exosome Delivery in Treating COVID-19 Lung Damage

Bruna Fonseca, Caio Fonseca, Michael Barros, Mark White, Vinay Abhyankar, David A. Borkholder, Sasitharan Balasubramaniam

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and cytokine storm) and mucoid debris that have filled lung alveoli, and reduced the surfactant tension resulting in heavy and stiff lungs. In this paper we propose the use of micro-bubbles filled with exosomes that can be released upon exposure to ultrasound signals as a possible rescue therapy in deteriorating COVID-19 patients. Recent studies have shown that exosomes can be used to repair and treat lung damage for patients who have suffered from the viral infection. We have conducted simulations to show the efficacy of the ultrasound signals that will penetrate through layers of tissues reaching the alveoli that contains the micro-bubbles. Our results have shown that ultrasound signals with low frequencies are required to oscillate and rupture the polymer-based micro-bubbles. Our proposed system can be used for patients who require immediate rescue treatments for lung damage, as well as for recovered patients who may suffer from viral relapse infection, where the micro-bubbles will remain dormant for a temporary therapeutic window until they are exposed to the ultrasound signals.

Original languageEnglish
Title of host publication2021 IEEE International Conference on Communications Workshops, ICC Workshops 2021 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728194417
DOIs
Publication statusPublished - Jun 2021
Event2021 IEEE International Conference on Communications Workshops, ICC Workshops 2021 - Virtual, Online
Duration: 14 Jun 202123 Jun 2021

Publication series

Name2021 IEEE International Conference on Communications Workshops, ICC Workshops 2021 - Proceedings

Conference

Conference2021 IEEE International Conference on Communications Workshops, ICC Workshops 2021
CityVirtual, Online
Period14/06/202123/06/2021

Keywords

  • COVID-19
  • Polymer-based Encapsulated Micro-bubbles
  • Ultrasound Communication

Fingerprint

Dive into the research topics of 'Ultrasound-based Control of Micro-Bubbles for Exosome Delivery in Treating COVID-19 Lung Damage'. Together they form a unique fingerprint.

Cite this