TY - GEN
T1 - Ultrasound-based Control of Micro-Bubbles for Exosome Delivery in Treating COVID-19 Lung Damage
AU - Fonseca, Bruna
AU - Fonseca, Caio
AU - Barros, Michael
AU - White, Mark
AU - Abhyankar, Vinay
AU - Borkholder, David A.
AU - Balasubramaniam, Sasitharan
N1 - Funding Information:
The research emanated from this publication is funded by the Waterford Institute of Technology Postgraduate Scholarship.
Publisher Copyright:
© 2021 IEEE.
PY - 2021/6
Y1 - 2021/6
N2 - The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and cytokine storm) and mucoid debris that have filled lung alveoli, and reduced the surfactant tension resulting in heavy and stiff lungs. In this paper we propose the use of micro-bubbles filled with exosomes that can be released upon exposure to ultrasound signals as a possible rescue therapy in deteriorating COVID-19 patients. Recent studies have shown that exosomes can be used to repair and treat lung damage for patients who have suffered from the viral infection. We have conducted simulations to show the efficacy of the ultrasound signals that will penetrate through layers of tissues reaching the alveoli that contains the micro-bubbles. Our results have shown that ultrasound signals with low frequencies are required to oscillate and rupture the polymer-based micro-bubbles. Our proposed system can be used for patients who require immediate rescue treatments for lung damage, as well as for recovered patients who may suffer from viral relapse infection, where the micro-bubbles will remain dormant for a temporary therapeutic window until they are exposed to the ultrasound signals.
AB - The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and cytokine storm) and mucoid debris that have filled lung alveoli, and reduced the surfactant tension resulting in heavy and stiff lungs. In this paper we propose the use of micro-bubbles filled with exosomes that can be released upon exposure to ultrasound signals as a possible rescue therapy in deteriorating COVID-19 patients. Recent studies have shown that exosomes can be used to repair and treat lung damage for patients who have suffered from the viral infection. We have conducted simulations to show the efficacy of the ultrasound signals that will penetrate through layers of tissues reaching the alveoli that contains the micro-bubbles. Our results have shown that ultrasound signals with low frequencies are required to oscillate and rupture the polymer-based micro-bubbles. Our proposed system can be used for patients who require immediate rescue treatments for lung damage, as well as for recovered patients who may suffer from viral relapse infection, where the micro-bubbles will remain dormant for a temporary therapeutic window until they are exposed to the ultrasound signals.
KW - COVID-19
KW - Polymer-based Encapsulated Micro-bubbles
KW - Ultrasound Communication
UR - http://www.scopus.com/inward/record.url?scp=85112801143&partnerID=8YFLogxK
U2 - 10.1109/ICCWorkshops50388.2021.9473613
DO - 10.1109/ICCWorkshops50388.2021.9473613
M3 - Conference contribution
AN - SCOPUS:85112801143
T3 - 2021 IEEE International Conference on Communications Workshops, ICC Workshops 2021 - Proceedings
BT - 2021 IEEE International Conference on Communications Workshops, ICC Workshops 2021 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 14 June 2021 through 23 June 2021
ER -