Unraveling the Roles of Morphology and Steric Hindrance on Electrochemical Analytical Performance of α-Fe2O3Nanostructures-Based Nanosensors towards Chloramphenicol Antibiotic in Shrimp Samples

Nguyen Ngoc Huyen, Ngo Xuan Dinh, Mai Quan Doan, Ngoc Phan Vu, Raja Das, Minh Tung Le, Pham Duc Thang, Anh Tuan Le

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, we investigated the effect of morphology on the analytical performance of α-Fe2O3 nanostructures-based electrochemical sensors toward chloramphenicol (CAP) antibiotic using three designed morphologies including α-Fe2O3 nano-Tube (α-Fe2O3-T), α-Fe2O3 nano-rice (α-Fe2O3-R), and α-Fe2O3 nano-plate (α-Fe2O3-P). Among these morphologies, α-Fe2O3-T displayed an outstanding electrochemical activity owing to the unique hollow structure and large specific surface area. However, due to the small pores size, α-Fe2O3-T showed the high steric hindrance (SD) effect towards an antibiotic with complex molecular structure, as CAP, leading to a significant decrease of their CAP electrochemical sensing performance. The CAP analytical performance of α-Fe2O3-R was highest in investigated morphologies owing to a high density of exposed Fe3+ as well as less SD effect towards CAP molecules. Under optimized conditions, α-Fe2O3-R-based CAP electrochemical sensor reached an electrochemical sensitivity of 0.92 uA uM-1 cm-2 with a LOD of 0.11 uM in the detection range from 2.5-50 uM. In addition, all these α-Fe2O3 nanostructures-based electrochemical sensors had excellent stability and high anti-interference ability for CAP analysis in a complex food matrix, as shrimp sample. This study provides valuable insights into the morphology-dependent sensing properties of α-Fe2O3 nanostructures towards antibiotics, which is helpful to the design of novel α-Fe2O3-based electrochemical nanosensors.

Original languageEnglish
Article number026507
JournalJournal of the Electrochemical Society
Volume169
Issue number2
DOIs
Publication statusPublished - 01 Feb 2022
Externally publishedYes

Keywords

  • chloramphenicol.
  • electrochemical nanosensors
  • morphology effects
  • steric hindrance
  • α-FeOnanostructures

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